What condition is most commonly associated with children born with Down Syndrome?

Children born with Down Syndrome, also known as Trisomy 21, frequently present with various health issues, but congenital heart disease is particularly prevalent among this population. Studies indicate that around 40-60% of infants with Down Syndrome have some form of congenital heart defect, which can range from minor to severe, impacting overall health and development.

Heart defects associated with Down Syndrome typically include atrioventricular septal defects, ventricular septal defects, and others that can affect the heart's ability to pump blood effectively. This association is significant and requires careful monitoring and potential interventions in children with Down Syndrome.

Understanding this connection is crucial for medical professionals who work with special populations, as early diagnosis and treatment of heart conditions can considerably improve outcomes. The other listed conditions—spina bifida, obesity, and autism spectrum disorder—are less commonly linked to Down Syndrome and are not as prevalent or direct as congenital heart disease.